Danae Schulz
Associate Professor of Biology
F.W. Olin Science Center, Room 2351
1250 N. Dartmouth Ave.
Claremont, CA 91711
909.621.8767
dschulz@qhtaobao.com
Education and Professional Experience
- B.A., Biology, Tufts University
- B.M.,小提琴演奏,新英格兰音乐学院
- Ph.D.加州大学伯克利分校分子与细胞生物学教授
- 洛克菲勒大学博士后研究员
- 巴德学院客座助理教授
Teaching
- Bio 111: Molecular Biology Lab (Fall)
- 生物189:生物化学和分子生物学主题(秋季)
- Bio 160: Molecular Immunology (Spring)
- Bio 52: Introduction to Biology (Spring)
- Bio 23: Biology Laboratory (Spring)
Research Interests
Danae studies the African trypanosome, 一种引起人类昏睡病和牛昏睡病的原生动物寄生虫. 锥虫通过采采蝇的叮咬传播到哺乳动物的血液中, eventually leading to coma and death. 达纳伊想了解是什么让锥虫重新编程以适应它们在苍蝇中肠和哺乳动物血液的不同环境之间移动, 着眼于试图操纵这些适应性来产生新的疗法. See also, Lab web page.
Website
Selected Publications
Parasite Papers
*表示本科共同作者,¨表示通讯作者
*Miller G, *Rollosson m, *Saada C, *Wade SJ, *Schulz D. 2023. Adaptation of CUT&RUN for use in African trypanosomes. PLoS One. 2023 Nov 21;18(11):e0292784. doi: 10.1371/journal.pone.0292784.
波利安,*Blyn RC, *Buenconsejo, GY, Hodanu M, Tang E, Danh C, Cassel J,Debler EW, *Schulz D ,Salvino, JM. 2023. 用于鉴定非洲锥虫蛋白靶点的I-BET151衍生物的合成和鉴定. Current Research in Chemical Biology. Volume 3, 2023, 100047. doi: 10.1016/j.crchbi.2023.100047
Azizan S, Selvarajah SA, Tang J, Jeninga MD, Schulz D,陈建军,陈建军,陈建军,陈建军,陈建军. 2023. The P. falciparum alternative histones Pf H2A.Z and Pf H2B.Z在异染色质边界被PfSir2组蛋白去乙酰化酶动态乙酰化和拮抗. mBio. 2023 Oct 26:e0201423. doi: 10.1128/mbio.02014-23
*Ashby, EC, *Havens, JL, *Rollosson, LM, Hardin, J,¨Schulz, D. 2023 Apr 25:e0014723. 昆虫期非洲锥虫中溴结构域蛋白的化学抑制扰乱了变异表面糖蛋白库的沉默并导致转录组的广泛变化. Microbiology Spectrum. doi: 10.1128/spectrum.00147-23
*Ashby EC, *Paddock L, *Betts HL, *Liao J, *Miller G, *Porter A, *Rollosson LM, *Saada C, Tang E, *Wade SJ, Hardin J, ¨Schulz D. 2022. 在非洲锥虫从血流型到前环型的分化过程中,溴结构域蛋白Bdf3的基因组占用是动态的. mSphere. 2022 Jun 1:e0002322. doi: 10.1128/msphere.00023-22.
*Walsh, ME, *Naudzius, EM, *Diaz, SJ, *Wismar, TW, Martchenko Shilman, M,¨Schulz, D. 2020. 鉴定临床批准的抑制生长和影响非洲锥虫发育调节基因转录水平的小分子. PLoS Negl Trop Disease. 2020 Mar 13;14(3):e0007790. doi: 10.1371/journal.pntd.0007790.
, , , , * , ¨ ,
Schulz, D. Mugnier, MR, Boothroyd, CE, Papavasiliou, FN. 2016. 磁活化细胞分选及流式细胞术检测表面糖蛋白转换. 视觉实验杂志,10月19日;(116). doi: 10.3791/54715
Schulz, D. Papavasiliou, F.N. 2016. 非洲锥虫单等位基因表达的棘手问题. Proc Natl Acad Sci U S A. Jun 17. pii: 201608546.
Mugnier, MR, Papavasiliou, FN, Schulz, D. 2016. Vesicles as Vehicles for Virulence. Trends Parasitol. 2016 Jun;32(6):435-6. doi: 10.1016.
Schulz, D, Papavasiliou, FN, Kim, HS. 2016. Base J and H3.V regulate transcriptional termination in Trypanosoma brucei. PLoS Genet 12(1): e1005762
Schulz D, Mugnier MR, Paulsen E-M, Kim H-S, Chung C-wW, Tough DF等. 2015. 溴结构域蛋白有助于维持非洲锥虫血液形态阶段的同一性. PLoS Biol 13(12): e1002316. [article]
Hovel-Miner G, Mugnier M, Papavasiliou FN, Pinger J, Schulz D. 2015. Springer, Results Probl Cell Differ. 57:23-46. 宿主-病原体相互作用的基本原理:抗原变异 Trypanosoma brucei. Springer, Results Probl Cell Differ. 57:23-46.
Immunology Papers
Schulz, D, Vassen, L, Chow, K, Amin, RA, Moroy, T, Schlissel, MS. Gfi1b直接或通过抑制fox01负性调控Rag的表达. 2012. 实验医学杂志,2009 (1):187-99.
Chow, KT, Schulz, D, McWhirter, SM, Schlissel, MS. Gfi1和Gfi1b在体外抑制浆细胞样树突状细胞中Rag转录. 2013. PLOS One. Sep24;8(9)e75891.
Schlissel, MS, Schulz, D, Vettermann, CA. 调节V(D)J重组的组蛋白编码. 2009. Molecular Cell, Jun 26;34(6):639-40.
Curry, JD, Schulz, D, Guidos, CJ, Danska JS, Nutter, L, Nussenzweig A, Schlissel MS. 在T细胞发育过程中,断裂的RSS末端染色体重新插入. 2007. J Ex Med, 204(10):2293-303
Degner SC, Verma-Gaur J, Wong TP, Bossen C, Iverson GM, Torkamani A, Vettermann C, Lin YC, Ju Z, Schulz D, et al. ccctc结合因子(CTCF)和内聚蛋白影响前b细胞中Igh位点的基因组结构和反义转录. 2011.美国国家科学院学报,6月7日;108(23):9566-71
DNA Repair Papers
Gellon L, Razidlo DF, Gleeson O, Verra L, Schulz D, Lahue RS, Freudenreich CH. Ctf18-RFC在姐妹染色单体内聚作用之外保持基因组稳定性的新功能. PLoS Genet. 2011 Feb 10;7(2):e1001298.